Columbia University and the Department of Neurology is recruiting a scientist for its Center for Translational & Computational Neuroimmunology (CTCN) and the Taub Institute for Research on Alzheimer’s disease and the Aging Brain.
The successful candidate will create a research program that is dedicated to exploring the role of the immune system and immune responses in neurological disease from a variety of perspectives. These perspectives include molecular genetics, molecular biology and cellular biology. This will include leveraging cutting-edge laboratory techniques, human samples and existing high-dimensional datasets from blood and aging human brains available at the CTCN. We are interested in comprehensive investigations of pathophysiology that integrate examination of the peripheral immune system with investigations of immune responses produced by a variety of CNS cells (microglia, astrocytes, endothelial cells, neurons…) and the interactions among these cell types.
Examples of areas of thematic interest for the CTCN include:
- Immune/glial cell interactions in health and disease
- Immunometabolism in the context of the central nervous system
- Role of the peripheral immune system in neurodegeneration
- Microglial subtype definition and characterization in neurodegeneration
- Immunopathology of auto-antibodies targeting central nervous system epitopes
We are looking for candidates that will lead the development of the next generation of mechanistic and target validation studies that emerge from the analysis of high-dimensional “omic” data. The position will involve participating in large multi-center “Team Science” projects as well as the development of independent, individual investigator-driven projects. Modeling human disease in vitro, especially with more complex culturing contexts is an advantage. Candidates who primarily wish to study mouse models would be considered non-responsive to the call for candidates. Ideally, candidates will develop extramural research support. Research and the teaching of graduate students, medical students, residents and postdoctoral fellows are important responsibilities for all departmental faculty.